Small GTPases in Disease, Part A

Chapter 1<br>Rab1b silencing using small interfering RNA for analysis of disease specific function<br>Darren M. Hutt, William E. Balch<br><br>Chapter 2<br>Rab8-optineurin-myosin VI: Analysis of interactions and functions in the secretory pathway<br>Margarita V. Chibalina, Rhys C. Roberts, Susan D. Arden, John Kendrick-Jones and Folma Buss<br><br>Chapter 3<br>Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate specific antigen in prostate carcinoma cells<br>Sergio D. Catz<br><br>Chapter 4<br>In vitro assays to characterize inhibitors of the activation of small G proteins by their guanine nucleotide exchange factors<br>Jean-Christophe Zeeh, Bruno Antonny, Jacqueline Cherfils, Mahel Zeghouf<br><br>Chapter 5<br>Analysis of small GTPase function in trypanosomes<br>Mark C. Field, David Horn and Mark Carrington<br><br>Chapter 6<br>Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis<br>Tom Kirchhausen, Eric Macia, Henry E. Pelish<br><br>Chapter 7<br>Identification and verification of Sro7p as an effector of the Sec4p rab GTPase<br>Bianka Grosshans1 and Peter Novick<br><br>Chapter 8<br>Characterization of Rab18, a Lipid Droplet Associated Small GTPase <br>Sally Martin, Robert G. Parton <br><br>Chapter 9<br>Analysis on the Emerging Role of of Rab3 GTPase-activating Protein in Warburg Micro and Martsolf Syndrome<br>Ayuko Sakane, Jun Miyoshi, Yoshimi Takai, Takuya Sasaki<br><br>Chapter 10<br>Identification and Characterization of JRAB/MICAL-L2, a Junctional Rab13-binding Protein<br>Noriyuki Nishimura and Takuya Sasaki<br><br>Chapter 11<br>A SMAP Gene Family Encoding ARF GTPase-activating Proteins and Its Implication in Membrane Trafficking<br>KENJI TANABE, SHUNSUKE KON, NOBUYUKI ICHIJO, TOMO FUNAKI, WAKA NATSUME, TOSHIO WATANABE, and MASANOBU SATAKE<br><br>Chapter 12<br>In vitro and in vivo analysis of neurotrophin-3 activation of Arf6 and Rac-1.<br>Pedro F. Esteban, Paola Caprari, Hye-Young Yoon, Paul A. Randazzo & Lino Tessarollo<br><br>Chapter 13<br>Methods for analysis of rab27a/munc13-4 in secretory lysosome release in haematopoietic cells<br>Peter van der Sluijs, Maaike Neeft, Thijs van Vlijmen, Edo Elstak, and Marnix Wieffer<br><br>Chapter 14<br>Analysis and expression of Rab38 in Oculocutaneous Lung Disease<br>Kazuhiro Osanai, Dennis R. Voelker<br><br>Chapter 15<br>Analysis of Rab1 function in cardiomyocyte growth <br>Guangyu Wu, Catalin M. Filipeanu, Fuguo Zhou<br><br>Chapter 16<br>Regulation of the Trafficking and Function of G Protein-coupled Receptors by Rab1 GTPase in Cardiomyoctyes<br>Guangyu Wu<br><br>Chapter 17<br>Regulation of endosome dynamics by Rab5 and its Huntingtin-HAP40 effector complex in physiological versus pathological conditions<br>Arun Pal, Fedor Severin, Sebastian Höpfner and Marino Zeria<br><br>Chapter 18<br>BIOCHEMICAL AND BIOPHYSICAL ANALYSES OF RAS MODIFICATION BY UBIQUITIN<br>Sonia Terrillon and Dafna Bar-Sagi <br><br>Chapter 19<br>Biochemical Characterization of Novel Germline BRAF and MEK Mutations in Cardio-facio-cutaneous Syndrome <br>Pablo Rodriguez-Viciana and Katherine A. Rauen<br><br>Chapter 20<br>Biochemical and biological characterization of tumor-associated mutations of p110a<br>Adam Denley, Marco Gymnopolous, Jonatha R. Hart, Hao Jiang, Li Zhao, Peter K. Vogt<br> <br>Chapter 21<br>Characterization of the Rheb-mTOR signaling pathway in mammalian cells: <br>Constitutive active mutants of Rheb and mTOR<br>Tatsuhiro Sato, Akiko Umetsu, Fuyuhiko Tamanoi<br><br>Chapter 22<br>Characterization of RalB-Sec5-TBK1 Function in Human Oncogenesis<br>Yuchen Chien and Michael A. White<br><br>Chapter 23<br>High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor<br>Ultan McDermott, Sreenath V. Sharma, Jeffrey Settleman<br><br>Chapter 24<br>In vitro signalling by MAPK and NFkB pathyways inhibited by Yersinia YopJ<br>Sohini Mukherjee, Kim Orth <br><br>Chapter 25<br>Biological and biochemical characterization of anthrax lethal factor, a proteolytic inhibitor of MEK signaling pathways. <br>Jennifer L. Bromberg-White and Nicholas S. Duesbery<br><br>Chapter 26<br>Genetic analyses of the role of RCE1 in RAS membrane association and transformation<br>Martin O. Bergo, Annika M. Wahlstrom, Loren G. Fong, Stephen G. Young<br><br>Chapter 27<br>Characterization of Kras Mediated Pancreatic Tumorigenesis in Zebrafish<br>Jon M. Davison, Seung Woo Park, Jerry M. Rhee, Steven D. Leach<br><br>Chapter 28<br>Genetic Modeling of Ras-Induced Human Rhabdomyosarcoma<br>Corinne M. Linardic, Christopher M. Counter